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Vyučující
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Anzenbacherová Eva, doc. RNDr. CSc.
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Galandáková Adéla, Ing. Ph.D.
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Obsah předmětu
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1. Key role of acetylcoenzyme A in metabolism. Tricarboxylic acid cycle (Citrate cycle), redox (respiratory) chain, aerobic phosphorylation. 2. Endocrine, paracrine and autocrine regulation of metabolic processes. 3. Metabolism of foreign compounds (xenobiotics). Function of the GIT, liver, kidney. 4. Oxidative stress, radicals, reactive oxygen species, nitric oxide, antioxidants. 5. Biochemistry of solid tissues. Osteosynthesis, osteolysis, osteoporosis. 6. Oral biochemistry Part I. Function of saliva, salivary diagnostics. 7. Oral biochemistry Part II. Saliva biomarkers.
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Studijní aktivity a metody výuky
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Monologická (výklad, přednáška, instruktáž), Dialogická (diskuze, rozhovor, brainstorming), Metody práce s textem (učebnicí, knihou), Metody písemných akcí (např. u souborných zkoušek, klauzur), Demonstrace, Laborování
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Výstupy z učení
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The aim of the subject is to explain theoretical principles of biochemistry and regulation mechanisms of basic metabolic pathways in eukaryotic cells. The emphasis is given on metabolic reaction in digestive organs and connective tissues, on the biochemistry of saliva and on the effect of diet on selected metabolic processes.
Students will acquire an overview of basic metabolic processes occurring in the body, including regulations. They will acquire basic knowledge required for interpretation of biochemical reactions in the buccal cavity and they will learn about the functions of saliva and about the causes of carries. From practical aspect, students will be able to carry out simple biochemical analyses including interpretation of results.
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Předpoklady
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Passing subject Medical chemistry.
LCH/ZAA11 a zároveň BIO/ZAB11 a zároveň NAN/ZAB11 a zároveň CJA/ZAB41 a zároveň LBF/ZAB11 a zároveň LCH/ZAA21 a zároveň CJA/ZAA41 a zároveň ST1/ZAA40 a zároveň ST1/ZAB40 a zároveň ST1/ZAB01 a zároveň HIE/ZAB11 a zároveň KAR/VAB11
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Hodnoticí metody a kritéria
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Známkou, Písemná zkouška, Esej
100% presence in practicals.
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Doporučená literatura
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Devlin, T. M. (2010). Textbook of Biochemistry with Clinical Correlations. John Wiley & Sons.
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Champe, P. C., Harvey, R. A., Ferrier, D. R. (2007). Biochemistry. Lippincott Williams & Wilkins.
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