| Course title | Organic Chemistry 1 |
|---|---|
| Course code | OCH/OC1 |
| Organizational form of instruction | Lecture + Seminar |
| Level of course | Bachelor |
| Year of study | not specified |
| Semester | Summer |
| Number of ECTS credits | 3 |
| Language of instruction | Czech |
| Status of course | Compulsory |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Lecturer(s) |
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| Course content |
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Organic Chemistry I provides information on chemical nomenclature, structure of basic organic skeletons, and their stereochemistry as well as their reactivity. Organic chemistry of the basic hydrocarbon skeletons. The subject of organic chemistry. Chemical bonds and bonding in organic molecules. Hybridization of the carbon atom, bonding energy, bond length, polarity of the chemical bond. Inductive and mesomeric effects on the chemical bonds, conjugation. General criteria of chemical reaction - reaction kinetics, reaction profiles and mechanism. Activation energy and enthalpy of the reaction. Chemical nomenclature. Alkanes and cycloalkanes, their chemical nomenclature. Chain isomerie, conformation analysis of alkanes and cycloalkanes (with stress on cyclohexane ring). Fused cyclic systems. Newmann projection. cis-trans Isomerism of cycloalkanes. Radical reactions as typical reactions of this system. Summary of radical reactions. Optical activity and symmetry of molecules. Chiral molecules, conditions of chirality. Methods of space objects presentation. Enantiomers, optical activity, specific rotation and its measurement, optical purity, racemic mixture. Molecules with more than one stereocenter. Cahn, Ingold, Prelog rules. Nomenclature of enantiomers. Meso compounds. Resolution of enantiomers. Alkenes, stereochemistry of double bond, cis-trans and E-Z nomenclature. Addition reactions, their summary with attention to the stereochemistry and mechanism. Polymerizations. Dienes and polyenes (cumulated, isolated, conjugated). Reactions of conjugated dienes, conditions and mechanism of 1,2- and 1,4-addition. Isoprenoides (monoterpenes, sesquiterpenes, di-, tri- and tetraterpenes, carotenes). Electronic spectra and relation between the structure and its spectrum. Pericyclic reactions - electrocyclic reactions, cycloaddition reactions, the rules of their realization, sigmatropic rearrangements. Akynes and their structure. Properties of the triple bond, addition reactions (electrophilic and nucleophilic additions), acidity of the hydrogen atoms bound on sp- carbon, pK$_a$. The phenomenon of aromaticity and its properties. Nonbenzoid aromates (polycyclic aromates, annulenes, aromatic ions.} Mechanism of aromatic electrophilic substitution. Summary of electrophilic reactions, formation of electrophilic reagents. Effect of substituents on the reactivity and orientation. Hammet equation, sigma and rho constants. Ipso substitution. Nucleophilic substitution on the aromatic ring (SN1, SN2, elimination-addition mechanism). Conditions for addition reactions and reactions of oxidation. Substitution a other reactions on fused aromatic compounds.
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| Learning activities and teaching methods |
| Lecture |
| Learning outcomes |
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Specialized course focusing on basic principles of organic chemistry.
Define main concepts, describe main approaches, present system of the organic chemistry. |
| Prerequisites |
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unspecified
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| Assessment methods and criteria |
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Written exam
Conditions for successful completion of the course OC1 1. Qualification of the written colloquium OC1 a) The student must successfully complete a total of two planned interim tests as part of the course OC1. b) The minimum percentage of each test must be at least 60%. c) In the event that one of the student progress tests fails or if the percentage in any one continuous tests at the proper time of less than 60%, is entitled to two of these terms. d) the terms and proper corrective terms will be reported to the teacher OC1 first lecture course OC1. Total will be set up to 1 and 2 proper correction terms. e) Individual written tests will be based on the curriculum of the course OC1. Retakes the semester will include already a curriculum subject OC1. f) Passing the credit is not recognized in the next academic year. 2. A written colloquium OC1 a) The right to participate in the colloquium written OC1 is the student who has met the conditions for qualification for the written colloquium OC1 (see point 1). b) Before the end of the course OC1 will be notified in advance of the terms of the written colloquium OC1. c) On the whole 7 terms of a written colloquium OC1 will be announced during the second half of May to the end of June. d) For successful completion of the course OC1 must be minimum percentage written colloquium OC1 least 70%. e) The student has a maximum of 3 attempts in a written colloquium. Each student is therefore available for one regular and two retakes written colloquium OC1. |
| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester | |
|---|---|---|---|---|
| Faculty: Faculty of Science | Study plan (Version): Chemistry (2019) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |
| Faculty: Faculty of Science | Study plan (Version): Nanomaterial Chemistry (2024) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |
| Faculty: Faculty of Science | Study plan (Version): Bioinorganic Chemistry (2021) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |
| Faculty: Faculty of Science | Study plan (Version): Chemistry for Education (2024) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |
| Faculty: Faculty of Science | Study plan (Version): Biochemistry (2022) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |
| Faculty: Faculty of Science | Study plan (Version): Bioorganic Chemistry and Chemical Biology (2020) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |
| Faculty: Faculty of Science | Study plan (Version): Chemistry - Analytical Specialist (2021) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Summer |