|
Lecturer(s)
|
-
Dvořák Zdeněk, prof. RNDr. DrSc.
-
Vrzal Radim, doc. Ing. Ph.D.
|
|
Course content
|
1. Principles of toxicology classification of toxic substances, undesirable effects spectra, dose-response relationship 2. Toxicology of food constituents I. 3. Toxicology of food constituents II. 4. Mathematical description of toxic compounds behavior in the body toxicokinetics 5. Nuclear receptors mediated endocrine disruption 6. Toxic effects of chemical warfare agents I. 7. Toxic effects of chemical warfare agents II. 8. Compounds with undesirable effects on mother and developing fetus I. 9. Compounds with undesirable effects on mother and developing fetus II. 10. Toxic effects of compounds on heart and vascular system 11. Signs of poisonings and their treatments for selected intoxications I. 12. Signs of poisonings and their treatments for selected intoxications II.
|
|
Learning activities and teaching methods
|
|
Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming)
|
|
Learning outcomes
|
The goal is to give an overview about the most known toxic compounds and to familiarize with molecular mechanisms of their toxic behavior.
After the course, the student will be able to name and discuss molecular mechanisms of toxic compounds action
|
|
Prerequisites
|
unspecified
|
|
Assessment methods and criteria
|
Written exam
- minimum 70% from written test - 3-5 minutes presentation
|
|
Recommended literature
|
-
Boelsterli, Urs A. (2007). Mechanistic toxikology: The molecular basis of how chemicals disrupt biological targets, 2nd edition.
-
Gupta, Ramesh C. (2009). Handbook of Toxicology of Chemical Warfare Agents, 1st edition.
-
Gupta, Ramesh C. (2011). Reproductive and Developmental Toxicology, 1st edition.
-
Klaassen, Curtis D. (2008). Casarett and Doull?s Toxicology: The basic science of poison, 7th edition.
|