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Lecturer(s)
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Vašut Radim Jan, doc. RNDr. Ph.D.
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Course content
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Student will get familiar with history on opinion about European colonisation by modern humans, modern methods in human evolution studies, variability of selected genetic markers and their interpretations, correlations between archaeological findings and modern genetic analyses. Marginally, we will discuss personal genealogic research using molecular methods. 1. Introduction, basic terms, population genetics, evolution, statistics 2. Early Evolution of the genus Homo 3. modern human (H. sapiens) and the Neaderthals (H. neanderthalensis) and their relationship 4. human colonisation of Europe, cultures, nation formation/definition 5. Y-chromosome analyse; Y-STR markers, variability, interpretation 6. mtDNA variability, interpretation, Seven daughters of Eve 7. personal molecular genealogy - examples 8. presenting seminar talks, discussion
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Projection (static, dynamic)
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Learning outcomes
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This course aims at introducing the evolution of modern humans in a light of population and evolutionary genetics. Although the main evolutionary relationships among hominids is drawn, the main aim of the course id to present the evolution and migration of modern humans during late Glacial Periods and in the Holocene (Paleolithic). The "Out of Africa" hypothesis is explained in detail based on mtDNA and Y-STR variability. Further evolution of early human society is discussed, especially the spread of neolthic farmers, changing cultural epoches and their impact on present genetic map of Europe. The course is ended by presenting molecular techniques in the modern genealogical reserach.
Student should be able to (after attending the course): - Recognize the main trends in modern humans evolution and migration - Define genetic background of the European society - Differentiate between mitochondrial and Y-chromosome human evolution - Differentiate genetic constitution of paleolithic, neolithic and recent populations of modern human in Europe - Define main Y-chromosome and mtDNA haplogroups/haplotypes - Describe the haplogroup/haplotype pattern in Czechia
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Prerequisites
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unspecified
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Assessment methods and criteria
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Seminar Work
Colloquium - seminar presentation (10-15 min) on given topics; discussion
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Recommended literature
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Cavalli-Sforza L. L. (2001). Genes, Peoples, and Languages. University of California Press, USA.
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Cavalli-Sforza L. L., Menozzi P., Piazza A. (1994). The History and Geography of Human Genes. Princeton University Press, Princeton.
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Clark D. P. (2010). Germs, Genes & Civilization: How Epidemics Shaped Who We Are Today. Upper Saddle River, NJ.
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Cochran G. & Harpending H. (2009). The 10.000 year Explosion. New York.
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Currat M., Excoffier L. (2005). The effect of the Neolithic expansion on European molecular diversity. Proc. R. Soc. B 272, 679-688.
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Jobling M. A., Hurles M. E. & Tyler-Smith C. (2004). Human Evolutionary Genetics: Origins, Peoples & Disease. New York, NY.
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Roberts A. (2011). Evolution: The Human Story. London.
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Sykes B. (2002). The Seven Daughters of Eve: The Science That Reveals Our Genetic Ancestry. W. W. Norton & Company.
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Torroni A. et. al. (2001). A Signal, from Human mtDNA, of Postglacial Recolonization in Europe. Am. J. Hum. Genet. 69:844-852.
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