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Lecturer(s)
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Fellnerová Ivana, RNDr. Ph.D.
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Course content
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1. Introduction to immunology: historical development of knowledge (Nobel Prize in immunology), basic terminology, IS components (organ, tissue, cellular, molecular), immune mechanisms (innate and adaptive immunity), IS ontogenesis and phylogeny overview. 2. Non-specific immunity ? components and displays: complement proteins, phagocytosis, TLR receptors; inflammation (classification, signals to development, course, microscopic and macroscopic displays of inflammation) 3. Apoptosis: apoptosis vs. necrosis, caspases, basic signalling paths 4. Specific (adaptive) immunity ? components and properties: specific receptors, clonal expansion, immunological memory. 5. Humoral immunity-B lymphocytes: BCR, immunoglobulin (Ig domain, isotopes), monoclonal and polyclonal antibodies, T lymphocyte-dependent and ?independent antibodies 6. Cellular immunity ? T lymphocytes: TCR, subpopulation of T lymphocytes (Tc, Th, Th17, Treg, NKT etc.), MHC molecules, HLA system; immunological tolerance 7. Immunogenetics: polymorphisms in IS, genetic basis of BCR or Ig and TCR forming, gene rearrangement, allelic exclusion; construction and heredity of MHC or HLA molecules 8. Bases of transplantation immunology: basic terminology, role of HLA molecules, immunosuppression principals 9. Immunology of viruses: basic overview of viruses, mechanisms of immune response to a viral infection, biology of influenza viruses, HIV, papillomaviruses and other examples 10. Disorders and diseases of the immune system: allergies, autoimmune diseases, HIV etc. 11. Tumours and immune system: how the immune surveillance can ?miss? tumour cells 12. Immunomodulatory therapy, biological therapy 13. Methods v immunology: examples of research, diagnostic and therapeutic methods
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Projection (static, dynamic)
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Learning outcomes
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The course aims at providing the students with a current overview of functioning of the immune system in a healthy and an ill human. The focus of the content is organs, tissues, cells and molecules of non-specific and specific immunity. Students learn about physiological functions of individual components of the immune system and their interactions. Further focus is put on the processes of emerging polymorphism of immunoglobulin and lymphocyte receptors. The issue of allergies and other types of hypersensitivity is explained, as well as the relation between the immune system and tumour growth, immune response to viral and bacterial infections and the role of the immune system in connection with transplantations. From the methodological point of view, the emphasis is put on students to realise the complexity of immune processes and thus to understand the broader relations in the IS as well as in connection to other human organ systems. With respect to the latest scientific knowledge, the functions of the immune system are presented on the cellular and molecular level with references to significant physiological medical discoveries and Nobel Prize. The lectures are interactive using multimedia technology incl. descriptive animations which facilitate the students? grasp of the complex interdependent immune processes taking place in a human body.
Student should be able to (after attending the course): - Describe the human immunology. - Describe the cells and organs of the immune system. - Explain the regulation of the immunity system.
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Prerequisites
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Elementary knowledge in biochemistry, essential and cell biology
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Assessment methods and criteria
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Written exam
colloquium - discussion in extent of the lectures
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Recommended literature
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* Výukové prezentace (dostupné na http://www.zoologie.upol.cz/ ).
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Abbas A. K., Lichtman A. H., Pillai S. * Cellular and molecular immunology (2007, 6th ed.): (vyd. Saunders Elsevier).
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Hořejší V., Bartůňková J. * Základy imunologie: 3. vyd. (2005) a výše.
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M. Vácha a kol.. * Srovnávací fyziologie živočichů, Brno 2010 ? kapitoly 9 a 10 (str. 56-75).
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Materiály poskytnuté vyučujícími na přednáškách a seminářích.
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Vrána A., Fellnerová I., Vránová J. * Imunologie a imunomodulační terapie, (2011) ? dostupné na http://cit.vfu.cz/fyziolmed/index.php/imunologie-a-imunomodulani-terapie.
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Abbas A. K., Lichtman A. H., Pillai S. (vyd. Saunders Elsevier). * Cellular and molecular immunology (2007, 6th ed.), (vyd. Saunders Elsevier).
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Hořejší, V., Bartůňková, J. (2017). Základy imunologie. Triton Praha.
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Janeway Ch. A., Murphy K., Travers P. * Janeway?s Immunobiology (2007, 7th ed.): (vyd. Garland Science).
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Janeway Ch. A., Murphy K., Travers P. (vyd. Garland Science). * Janeway?s Immunobiology (2007, 7th ed.): (vyd. Garland Science).
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M. Vácha a kol., Brno 2010 ? kapitoly 9 a 10 (str. 56-75). *Srovnávací fyziologie živočichů.
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Vokurka M., Hugo J. * Velký lékařský slovník (2005, 5.vydání a výše): (vyd. Jessenius Maxdorf).
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Vokurka M., Hugo J. (vyd. Jessenius Maxdorf). * Velký lékařský slovník (2005, 5.vydání a výše): (vyd. Jessenius Maxdorf).
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Vrána A., Fellnerová I., Vránová J. (2011). * Imunologie a imunomodulační terapie: dostupné na http://cit.vfu.cz/fyziolmed/index.php/imunologie-a-imunomodulani-terapie.
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