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Lecturer(s)
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Modrianský Martin, prof. Mgr. Ph.D.
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Course content
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The task of the course is to familiarize students with the basics of biochemical processes in the human body from cellular compartmentalization to individual tissues. Seminars include discussions on biochemical parameters that are used in clinical diagnostics. Individual thematic areas are arranged as follows: 1. Structure, properties and functions of amino acids, amino acid metabolism, peptides/proteins and their role in the body. 2. Structure, properties and functions of carbohydrates/polysaccharides, carbohydrate metabolism including hormonal regulation, diabetes mellitus and its complications. 3. Structure, properties and functions of lipids, lipid metabolism, lipoprotein particles and their functions in the body. 4. Structure, properties and functions of nucleotides, base metabolism, regulation of transcription and translation. 5. Overview of elements that perform specific functions in the body (ions, transition metals), their metabolism and consequences of imbalance. 6. Vitamins: overview of structures and functions, their absorption and metabolism. 7. Biochemistry of liver tissue and digestive tract. 8. Biochemistry of the kidneys, including hormonal function and influence on acid-base balance. 9. Biochemistry of vision, biochemical basis of vision disorders.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Demonstration, Projection (static, dynamic)
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Learning outcomes
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The aim of the subject is to explain teoretical principles of biochemistry, clinical biochemistry and regulatory mechanisms of basic metabolic pathways. This knowledge is essential for interpretation of physiological and pathological events in human organism. Students are also trained in laboratory classes to master simple biochemical analyses and to interpret the results of laboratory tests in differential diagnostics and therapy.
The student who passes the subject will be equipped with theoretical knowledge on basic biochemical pathways and information on regulation of intermediary metabolism. Student will be able to interpret physiological and pathological events in human prganism. In practice, students will be able to work according to good laboratory practice rules and to perform basic biochemical tests and to interpret laboratory results in a procedure of differential diagnosis and therapy. By acquiring all above mentioned skills the student will be able to utilize them in specialized fields of internal medicine that will follow.
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Prerequisites
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Basic knowledge of high school biochemistry.
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Assessment methods and criteria
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Mark, Oral exam, Seminar Work
Test.
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Recommended literature
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Matouš, B. (2010). Základy lékařské chemie a biochemie. Galén.
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Paulová, H. a kol. (2021). Biochemie pro nelékařské zdravotnické obory.. Masarykova Univerzita.
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Racek, J., Rajdl, D. (2021). Klinická biochemie. Praha, Galén.
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Zima, T. a kol. (2007). Laboratorní diagnostika. Galén, Praha.
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