Seminar follows-up lecture Fundamental organic chemistry and it is focused on practice explained subject matter according to contents of lecture. At seminar there are again explained general problems to students. These ones, subsequently, solve problem with concrete examples. For better understanding of problems, students are duty to work up their homework. Results of their effort are analyzed next seminar. Students will be able to obtain examples for practicing from electronic textbook. This e-textbook will contain both tasks and solved tasks. Within term at seminar students will solve tests on their own to verify if they understand of problems of organic chemistry. Program of seminar: 1. Structure of organic molecules and their presentation. Models, kinds of structural formulas. Projection and spatial formulas, Isomerism and its kinds. Geometrical and optical isomerism, exercise to specific examples. 2. Nomenclature of organic compounds. Nomenclature of basic skeletons. 3. Nomenclature of organic compounds with presence of functional groups, their priority. 4. Basic terms in organic chemistry. Bonding and steric factors. Types of organic reactions, agents and their classification. Relationship between structure, properties and reactivity of organic compounds. Effects in molecules 5. Alkanes - properties, synthesis, reactivity. Alkenes - properties, synthesis, reactivity. Addition reactions. Dienes and polyenes - cumulated, isolated, conjugated. Alkynes - properties, synthesis, reactivity. Reppe syntheses. Comparison of each other from view of reactivity. 6. Aromatic compounds - properties, synthesis and reactivity. Mechanism of aromatic electrophilic substitution. Summary of electrophilic reactions, formation of electrophilic reagents. Effect of substituents on the reactivity and orientation. 7. Halogenderivatives - properties, synthesis, reactivity. Nucleophilic substitution. Stereochemical view to SN reactions. Elimination reactions. Hydroxyderivatives - properties, synthesis, reactivity. Ethers, organic peroxides, thioles, sulfides - properties, synthesis, reactivity. Strategy of the mutual transformation of functional groups. 8. Nitrogen containing compounds. Nitroso and nitro compounds. Hydroxylamines, amines, diazocompounds. Diazoalkanes, properties, synthesis, reactivity. Strategy of the mutual transformation of functional groups. 9. Carbonyl derivatives - properties, synthesis, reactivity. Nucleophilic addition. Acidic and basic catalyzed reactions. Strategy of the mutual transformation of functional groups. 10. Carboxylic acids, their structure, representatives, chemical properties. Function derivatives of carboxylic acids (esters, halogen derivatives, amides, anhydrides). Substituted derivatives of carboxylic acids (hydroxyacids, lactones, lactides, aminoacids, lactams, halogenacids, ketoacids). Retrosynthetic approach to more komplex organic molecules. 11. Heterocyclic compounds - classification of heterocycles, general approach to properties and syntheses of five and six membered heterocycles. Retrosynthetic approach to more complex organic molecules. 12. Carbohydrates, lipids, proteins and nucleic acids. 13. Outlining of synthesis of some naturally compounds. 14. Final test
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Červinka O., Dědek V., Ferles M. (1980). Organická chemie . SNTL Praha.
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McMurry J. . (2007). Organická chemie . Praha.
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Slouka J, Fryšová I., Cankař P. (2010). Průvodce některými úvodními kapitolami organické chemie . UP Olomouc.
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Solomons G., Fryhle C. (1999). Organic Chemistry 7th . John Wiley & Sons, New York .
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