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Lecturer(s)
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Šebela Marek, prof. Mgr. Dr.
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Course content
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1. Enzyme models and mimics 2. Functionalized cyclodextrines as enzyme catalysts 3. Synthetic polymers and dendrimers as a part of artificial enzymes 4. Natural polypeptides functionalization 5. Metalocomplexes as catalysts 6. Aminotransferases, decarboxylases and hydrolases mimics 7. Directed halogenations 8. Hydroxylations as mimics of cytochrome P450 reactions 9. Antibodies as artificial enzymes 10. Carbon-based, metal-based and metal oxide-based nanozymes
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
- Homework for Teaching
- 50 hours per semester
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Learning outcomes
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This subjected is for students of the doctoral study program Organic and bioorganic chemistry.The subject aims at transferring knowledge on the following topics: 1. Enzyme models and mimics 2. Functionalized cyclodextrines as enzyme catalysts 3. Synthetic polymers and dendrimers as a part of artificial enzymes 4. Natural polypeptides functionalization 5. Metalocomplexes as catalysts 6. Aminotransferases, decarboxylases and hydrolases mimics 7. Directed halogenations 8. Hydroxylations as mimics of cytochrome P450 reactions 9. Antibodies as artificial enzymes 10. Carbon-based, metal-based and metal oxide-based nanozymes
A successful completion will verify and confirm knowledge of the discipline acquired during studies.
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Prerequisites
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The prerequisite is the knowledge of biochemistry and organic chemistry at the level of fundamental lectures.
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Assessment methods and criteria
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Oral exam
The candidate is expected to conduct scientific discussion in a broader context of the whole discipline.
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Recommended literature
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Breslow, R. (Ed.). (2005). Artificial enzymes. Wiley-VCH.
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Wang, X.; Guo, W.; Hu, Y.; Wu, J.; Wei, H. (2016). Nanozymes: next wave of artificial enzymes. Springer.
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