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Lecturer(s)
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Markos Athanasios, RNDr. Ph.D.
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Cankař Petr, doc. RNDr. Ph.D.
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Course content
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- Morphine and its congeners: isolation, structural analysis, biosynthesis, total synthesis, structure modification, structure vs. biological activity - Modern synthetic methods for pharmaceutical compounds and their intermediates - Protecting groups - Peptides - Why and how to visualize interactions of small molecules and proteins in 3D: protein kinase inhibitors - Synthesis of organic compounds in practice
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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The seminar is desgned to connect knowledges of basic subjects in the area of organic chemistry. Students will learn to solve complex problems on several model topics.
Ability to design a complete synthesis of chemical compounds.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Student performance
The credit will be granted upon acquittance of chosen tasks and attendance stated by the study rule.
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Recommended literature
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Červinka O. a kol. (1987). Chemie organických sloučenin. SNTL Praha.
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Červinka O. (1981). Mechanismy organických reakcí. SNTL, Praha.
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Hradil, P. (2007). Moderní metody organické syntézy v reakčních schématech. Olomouc: Univerzita Palackého.
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McMurry J. . (2007). Organická chemie . Praha.
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Moloney M. G. (2000). Reaction Mechanisms at a Glance. Blackwell Science Ltd., England.
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Patrick, H. T., Yulin, L. (2012). Solid-Phase Organic Synthesis: Concepts, Strategies and Applications. Wiley & Sons, Inc.
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