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Lecturer(s)
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Čížková Kateřina, doc. Mgr. Ph.D.
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Kolář Zdeněk, prof. MUDr. CSc.
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Course content
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Fundamentals of molecular pathology; Predictive and prognostic pathology; Fundamentals of oncology; Carcinogenesis, oncogenes, tumor suppresors, cancer stem cells, types of cell death; Current and emerging therapies of cancer. Basic concepts of general and molecular pathology and methodological basis; Predictive and prognostic pathology; basics of oncology, types of tumors and definitions (TNM classification, grading, invasive growth and metastasis); process of carcinogenesis, oncogenes and tumor suppressors, apoptosis and other types of cell death, theory of tumor stem cells; standard cancer therapy and translation of new therapies into practice (targeted therapy, antibodies, gene therapy, tumor vaccines and immunotherapy). 1. Basic concepts of pathology and methodological basis 2. Predictive and prognostic pathology 3. Basics of oncology, types of tumors and definitions (TNM classification, grading, invasive growth and metastasis) 4. Process of carcinogenesis, oncogenes and tumor suppressors, apoptosis and other types of cell death, theory of tumor stem cells 5. Standard tumor therapy and translation of new therapies into practice (targeted therapy, monoclonal humanized antibodies, gene therapy, tumor vaccines and immunotherapy) 6. Basics of histology (cellular, tissue and organ context for knowledge of molecular biology and genetics
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Learning activities and teaching methods
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Lecture
- Homework for Teaching
- 25 hours per semester
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Learning outcomes
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Fundamentals of molecular pathology.
Describe and explain: Fundamentals of molecular pathology; Predictive and prognostic pathology; Fundamentals of oncology; Carcinogenesis, oncogenes, tumor suppresors, cancer stem cells, types of cell death; Current and emerging therapies of cancer.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Mark
80% fruitfulness in exam
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Recommended literature
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Cagle PT and Craig T:. (2009). Basic concepts of molecular pathology.. Springer, 2009.
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Hanahan et Weinberg. (2011). Hallmarks of Cancer: The Next Generation..
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Junqueira C. (2007). Basic histology.. Academic Internet Publishers, 2007.
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Junqueira, C.L. a kol. (2002). Základy histologie. Nakladatelství H+H.
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Kolář Z. a kol. (2003). Molekulární patologie nádorů. Epava, Olomouc.
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Macháček, J., Ćwiertka, K. (1996). Základy radiační a klinické onkologie. Olomouc: VUP.
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Tubbs RT and Stoler MH:. (2009). Cell and tissue based molecular pathology..
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Weinberg, R.A. (2013). The Biology of Cancer. Garland Science.
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Weinberg, R.A. (2007). The Biology of Cancer. Garland Science.
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