|
Lecturer(s)
|
-
Jourová Lenka, Mgr. Ph.D.
-
Anzenbacherová Eva, doc. RNDr. CSc.
|
|
Course content
|
Enzymes - structure, function, classification. Cofactors and vitamins. Enzymes in diagnosis. Citric acid cycle. Bioenergetics, biological oxidation, respiratory chain, oxidative phosphorylation. Aminoacids, peptides, proteins - structure, properties. Digestion of proteins. Metabolism of aminoacids and proteins, urea cycle. Saccharides: structure, properties. Digestion of saccharides. Metabolism of saccharides: glycolysis, gluconeogenesis, glycogen metabolism, pentose phosphate pathway. Lipids: structure, properties. Lipid metabolism: digestion, transport in blood, lipoproteins, fatty acid - oxidation, fatty acid biosynthesis ketone bodies, triacylglycerol metabolism. Cholesterol metabolism. Tetrapyrroles - hemoglobin and bile pigments. Nervous tissue, muscle, bone - structure, function. Nucleotides - structure, function. Hormons: overview, function. Regulation of metabolism.
|
|
Learning activities and teaching methods
|
|
Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Demonstration, Laboratory Work
|
|
Learning outcomes
|
Students learn the basic principles of biochemistry and metabolic regulation to the extent necessary for interpretation of physiological and pathophysiological events in the human organism. In the practical part, they have to be able to follow the principles of good laboratory practice, perform simple biochemical analyses and evaluate the results of simple laboratory tests.
Students will be able to apply acquired knowledge in the therapy of patients.
|
|
Prerequisites
|
Basic knowledge of high school biochemistry.
|
|
Assessment methods and criteria
|
Mark, Oral exam, Written exam
Active attendance in practicals, written test.
|
|
Recommended literature
|
-
Dobrota, D. (2012). Lekárska biochémia. Martin: Osveta.
-
Dvořáčková, S. (2013). Pracovní sešit z biochemie. Olomouc.
-
Ledvina, M. a kol. (2009). Biochemie pro studující medicíny (1. a 2. díl). Praha - Karolinum, UK.
-
Matouš, B. (2010). Základy lékařské chemie a biochemie. Galén.
-
Skálová, L. (2014). Základní biochemické dráhy v buňce. Praha: Karolinum.
-
Tomandl, J. (2014). Základy lékařské chemie a biochemie. Brno: Masarykova univerzita.
-
VOET, D., VOET, G. J., PRATT, W. Ch. Fundamentals of biochemistry: life at the molecular level.
|