| Course title | Physical Chemistry Focused on Reactivity of Molecules |
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| Course code | KFC/PGFRM |
| Organizational form of instruction | no contact |
| Level of course | Doctoral |
| Year of study | not specified |
| Semester | Winter and summer |
| Number of ECTS credits | 5 |
| Language of instruction | Czech, English |
| Status of course | Compulsory-optional |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Lecturer(s) |
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| Course content |
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Importance of kinetics and mechanism of chemical reactions. Study of equilibrium processes. Acid-base equilibria. Generalized acidity functions. Study of chemical reactions. Internal and external factors influencing reactivity of educts. Simple and complex kinetic equations. Physical and chemical methods for determination of reaction rates. Evaluation of experiments. Thermodynamics of chemical reactions. Principle of similarity and its application. Salt effects. Bodenstein approximation of quasi-stationary state. Subsequent reactions. Pre-equilibrium. Determination of activation parameters of chemical reaction. Classification of solvents and their influence on chemical reactivity. Empirical and semi-empirical parameters of solvent polarity. Solvent effects of mixed solvents. Nucleophilicity and its quantitative description. Isotope effects. Substitution effects. Bronsted relationship. Substitution effects, Hammett equation. Quantitative description of substitution effects based on separation of effects. Application of physical methods in the study of relationships between structure and properties of organic compounds. Application of physical methods in the study of mechanisms of organic reactions. Relationships between the structure of organic compounds and their biological activity.
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| Learning activities and teaching methods |
| unspecified |
| Learning outcomes |
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The aim of the exam is to guarantee that the doctoral student has knowledge of physical chemistry important for the reactivity of molecules.
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| Prerequisites |
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unspecified
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| Assessment methods and criteria |
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unspecified
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| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester | |
|---|---|---|---|---|
| Faculty: Faculty of Science | Study plan (Version): Physical Chemistry (2021) | Category: Chemistry courses | - | Recommended year of study:-, Recommended semester: - |
| Faculty: Faculty of Science | Study plan (Version): Physical Chemistry (2021) | Category: Chemistry courses | - | Recommended year of study:-, Recommended semester: - |
| Faculty: Faculty of Science | Study plan (Version): Physical Chemistry (2021) | Category: Chemistry courses | - | Recommended year of study:-, Recommended semester: - |
| Faculty: Faculty of Science | Study plan (Version): Physical Chemistry (2021) | Category: Chemistry courses | - | Recommended year of study:-, Recommended semester: - |