|
Lecturer(s)
|
-
Gabriel Roman, Ing. Ph.D.
-
Berka Karel, doc. RNDr. Ph.D.
|
|
Course content
|
The lectures include the fundamentals of material chemistry of pharmaceutical substances with particular emphasis on the theory of crystallization, crystallization processes at pharmacy, on physical chemical properties of pharmaceutical substances and analytical procedures used for characterization of solid materials. 1. Introduction to the study of solids (classification and properties). 2. Preparation of solids (heterogeneous systems, phase changes, nucleation). 3. Crystalline substances 1 (crystalline state, physical and thermal properties of crystalline substances). 4. Crystalline substances 2 (solutions and solubility, phase equilibrium). 5. Fundamentals of the crystallization process (nucleation. crystal growth, recrystallization). 6. Crystallization at pharmaceutical industry (batch crystallization, thermodynamic and kinetic crystallization). 7. Polymorphism 1 - property of crystalline solids. 8. Polymorphism 2 - analytical methods for characterization 9. Polymorphism of pharmaceutical compounds (impact on the properties of pharmaceutical substances). 10. The importance of solvates, hydrates and amorphous solids. 11. X-ray powder diffractometry and thermal methods of analysis of powders. 12. Particle Morphology: Optical and Electron microscopies 13. Physical and mechanical property characterization of powders. 14. Summary.
|
|
Learning activities and teaching methods
|
Monologic Lecture(Interpretation, Training)
- Preparation for the Exam
- 60 hours per semester
|
|
Learning outcomes
|
This lecture course deals with solid crystalline compounds from the material chemical point of view, predominantly from the point of view of pharmaceutical chemistry.
ability to define main concepts, describe crystalline compounds related to pharmaceutical chemistry
|
|
Prerequisites
|
unspecified
|
|
Assessment methods and criteria
|
Oral exam
Attendance is not obligatory but is strongly recommended. Examination is oral. Students sitting the examinations should be able to discuss two chosen questions.
|
|
Recommended literature
|
-
Bernstein, J. (2002). Polymorphism in Molecular Crystals.,. Oxford Press.
-
Brittain, H. G. (ed.). (1999). Polymorphism in Pharmaceutical Solids., Vol. 95. Marcel Dekker, New York.
-
Kratochvíl B., Švorčík V., Vojtěch D. (2005). Úvod do studia materiálů.,. VŠCHT Praha.
-
Mulin, J.W. (2001). Crystallization. 4th. edn.,. Butterworth-Heinemann Ltd., Oxford.
|