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Lecturer(s)
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Bělíček Jakub, Mgr.
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Hájek Libor, Ing.
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Kryštof Vladimír, prof. RNDr. Ph.D.
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Course content
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Scientific literature. General bibliographic databases (Pubmed, Web of Science, EBSCO, ProQuest, etc.). Full-text databases, general and publisher. Biotechnological and biomedical databases (NCBI, ExPASy, EMBL-EBI, HGNC). Sequence and structure databases. Comparison of nucleic acids and protein sequences. Searching for genes. Functional genomics. Classification of proteins and proteomics. Posttranslational modifications of proteins. Phylogenetic studies and comparative genomics.
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Learning activities and teaching methods
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Lecture, Work with Text (with Book, Textbook), Demonstration, Laboratory Work
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Learning outcomes
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The aim of the course is to teach students how to effectively search, evaluate, and use information resources in biology and medicine, including databases of scientific literature, patents, chemical compounds, and bioinformatics resources.
The student can effectively search for scientific articles in databases (PubMed, Web of Science, Scopus), is familiar with patent databases (Espacenet, WIPO, USPTO), knows how to search for information on chemical compounds (Reaxys, PubChem, ChEMBL), is able to use bioinformatics databases (PDB, UniProt, Ensembl) for individual work, can perform basic gene sequence analyses (alignment, phylogenetic tree construction), is able to design PCR primers and carry out the theoretical preparation of DNA cloning,can cite and correctly handle scientific literature.
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Prerequisites
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Basic knowledge of biology and chemistry at the bachelor's level. Basic computer and internet skills.
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Assessment methods and criteria
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Written exam, Seminar Work
Full participation at the seminars is required, 80% successfull passing the test
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Recommended literature
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Baxevanis AD, Ouellette BFF. (2004). Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. WileyBlackwell; 3rd Edition edition.
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Bishop, M.J. (1999). Genetics Databases. Academic Press.
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Claverie, J.M. (2006). Bioinformatics for Dummies. John Wiley & Sons; 2nd Edition edition.
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Sadek, H.A. (2006). Bioinformatics: Principles and Basic Internet Applications. Trafford Publishing.
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