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Lecturer(s)
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Divoký Vladimír, doc. RNDr. Ph.D.
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Course content
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The course aims at explaining the molecular background of tumour tarnsformation. The main attention is paid to explanation of deregulation of signal pathways in malignant cells. Particular topics: oncogenes, tumour supressors and other signal moleculs in tumour transformation, tumour stem cell, cancerogenesis, two-impact model, predispositions to tumours, role of the chromatin changes in tumour development. Apoptosis of the tumour cell. Molecular mechanisms of the effect of classical and direkt-antitumour treatments. Molecular background of the resistence of tumour cells to cytostatics.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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The course aims at explaining the molecular background of tumour tarnsformation.
Student is able to (after attending the course): - Explain the molecular background of tumour transformation. - Explain and described factors of cancerogenesis - Describe the apoptosis of the tumour cell. - Explain the molecular mechanisms of the effect of classical and direct-antitumor treatments.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral exam
oral exam in extent of the lectures
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Recommended literature
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Kolář Z. a kol. (2003). Molekulární patologie nádorů. Epava, Olomouc.
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Mendelson J., Howley P.M., Israel M.A., Liotta L.A. The Molecular Basis of Cancer. 2nd edition; W.B. Saunders, 1995.
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Nečas E. a kolektiv. Obecná patologická fyziologie. Karolinum, Praha, 2000.
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