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Lecturer(s)
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Vrzal Radim, doc. Ing. Ph.D.
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Course content
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History of genetics, Counselling, Prenatal diagnosis, Genetic defects therapy, Chromosomes - analysis, chromosomal aberration, Mendel's laws of Inheritance, Sex linked inheritance, Assisted reproduction, Genetics of mitochondrial disorders, Molecular genetics of muscle diseases, Molecular genetics of neurological diseases, Molecular genetics of eye, Genetics of immunity, Genetics of behavior.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming)
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Learning outcomes
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Principles og human genetics, autosomal, gonosomal and mitochondrial disorders and their genetic treatment, aplication of molecular biology. Ethics vs. Genetics.
Student is able to (after attending the course): - Describe individual proportions of important and perspective branch - List selected genetic diseases, their causes and manifestations - Explain the reasons of different type of chromosomal aberrations as causes genetic diseases - Describe the principles of cytogenetic and molecular-cytogenetic methods of chromosomal aberrations detection
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written exam, Essay
60% from test in extent of syllabus + seminar work
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Recommended literature
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Brooker. (2014). Analysis and Principles. McGraw-Hill Education, 5 th edition.
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Hatina, J., Sykes, B. Lékařská genetika, problémy a přístupy. Academia Praha, 1999.
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Kingston, H. M. ABC of Clinical Geneteics. 3rd edition, BMJ Books 2002.
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Kočárek E., Pánek M., Novotná D. (2006). Klinická cytogenetika I.. Skriptum UK 2. LF, Karolinum, Praha.
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Lewin B., Krebs J.E., Goldstein E.S., Kilpatrick S.T. Lewin's GENES XI.
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Lewis R. (2010). Human Genetics, Concepts and Aplications, 9th edition. The McGraw-Hill Companies.
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Pasternak J. J. An Introduction to human molecular genetics - Mechanisms of inherited diseases, 2nd edition, A John Wiley and Sons, Inc., 2005.
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Pierc B.A. (2014). Genetics: A Conceptual Approach, 5th edition. W. H. Freeman.
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Snustad D. P., Simmons M. J. (2009). Genetika. asarykova univerzita, Brno, 1. vydání.
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Strachan, T., Read A. (2011). Human molecular genetics. Garland Science, Taylor & Francis Group, LLC.
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