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Lecturer(s)
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Nemec Ivan, doc. Ing. Ph.D.
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Herchel Radovan, doc. Ing. Ph.D.
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Berka Karel, doc. RNDr. Ph.D.
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Course content
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1. Chemical bond and its properties. 2. Non-covalent interactions - van der Waals interactions, hydrogen bond. 3. Molecular structure - constitution, configuration, conformation. 4. Proteins, nucleid acids, saccharides, lipides - composition and basic structural features. 5. Proteins, nucleid acids, saccharides, lipides - occurence and roles in organisms. 6. Factors determining 3D biomolecular strucutre - structure propeties relationships. 7. Separation and isolation of biomacromolecules. 8. Biomolecular crystallography. 9. Biomolecular NMR. 10. Biomolecular mass spectrometry. 11. Theoretical methods in biomacromolecular structure investigation. 12. Basic protein engineering.
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Work with Text (with Book, Textbook)
- Homework for Teaching
- 50 hours per semester
- Preparation for the Exam
- 50 hours per semester
- Attendace
- 26 hours per semester
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Learning outcomes
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Prerequisites
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Knowledge of issues presented within basic courses of general, physical, organic chemistry and biochemistry. Basic knowledge of principles of physico-chemical methods for atoms and molecules structure and properties analysis.
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Assessment methods and criteria
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Oral exam
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Recommended literature
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& Chance, M. (2008). Mass spectrometry analysis for protein-protein interactions and dynamics. Hoboken, N.J: Wiley.
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Evans, J. N. S. (1995). Biomolecular NMR spectroscopy. Oxford: Oxford University Press.
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Lipton, M. S., & Paša-Tolić, L. (2009). Mass spectrometry of proteins and peptides: methods and protocols. [New York]: Humana Press.
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Malinowski B. (2007). Sex a represe v divošské společnosti. Praha: Slon.
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Rupp, B. (2010). Biomolecular crystallography: principles, practice, and application to structural biology. New York, N.Y: Garland Science.
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Seader, J. D., Henley, E. J., & Roper, K. D. (2011). Separation process principles: chemical and biochemical operations. Hoboken, N.J: John Wiley & Sons.
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Sheehan, D. (2000). Physical biochemistry: principles and applications. Chichester: John Wiley and Sons.
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Tinoco, I., Sauer, K., & Wang, J. C. (1985). Physical chemistry: principles and applications in biological sciences. Englewood Cliffs: Prentice-Hall.
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