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Lecturer(s)
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Fryčák Petr, doc. RNDr. Ph.D.
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Course content
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1. Introduction to clinical and forensic toxicology. 2. Objectives of toxicological tests. Pharmacokinetics, metabolism (absorption - distribution - elimination - accumulation of noxes). Pharmacodynamics 3. Biotransformation. Poisoning, overdose, toxic levels, Nox interaction. General approaches to the treatment of acute intoxication. 4. Laboratory diagnosis of poisoning, drug abuse, the choice of samples, detection limits and detection time window. Trends in analytical toxicology (current toxicological methods, strengths and limitations - Validation of toxicology methods) 5. Alternative materials with respect to the drug identification (Saliva - Meconium - Hair) 6. Legislation in relation to substance abuse treatment 7. Practical information on acute poisoning 8. The main types of drugs and drug addiction (Cannabinoids, central stimulants, substances with central-depressant effect, Solvencia, opiates / opioids, analgesic compounds, Tobacco, Alcohol)
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Learning activities and teaching methods
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Lecture
- Attendace
- 26 hours per semester
- Homework for Teaching
- 13 hours per semester
- Preparation for the Exam
- 21 hours per semester
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Learning outcomes
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The goal of this course is to acquaint students with the problems of clinical toxicology, the effects of drugs, illegal substances and drugs and poisons on the human organism. Students will be acquainted with the metabolism of those substances and methods of their license and identification in body fluids and the evaluation results for forensic purposes.
The student knows the basics of clinical toxicology and is able to apply its findings and conclusions in forensic investigations. It is able to communicate with other professionals cooperating in the investigation of criminal offenses.
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Prerequisites
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The knowledge of basics of analytical chemistry and instrumental methods of analytical chemistry is recommended.
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Assessment methods and criteria
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Oral exam
To pass an exam - oral examination, 3 questions
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Recommended literature
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BALÍKOVÁ, Marie. Forenzní a klinická toxikologie: laboratorní toxikologická vyšetření. 2., doplněné vydání. Praha: Galén, 2017. 127 s..
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BARILE, Frank A. Barile's Clinical Toxicology: Principles and Mechanisms. 3rd edition. Boca Raton: CRC Press, 2019. 622 s..
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BASELT, Randall C. Disposition of Toxic Drugs and Chemicals in Man. 12th edition. Seal Beach: Biomedical Publications, 2020. 2343 s..
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GUCKÝ, Tomáš. Toxikologie omamných a psychotropních látek. 1. vydání. Olomouc: Univerzita Palackého v Olomouci, 2015. 171 s..
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LEVINE, Barry S. a Sarah KERRIGAN (eds.). Principles of Forensic Toxicology. 5th edition. Cham: Springer, 2020. 691 s..
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LINHART, Igor. Toxikologie: interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky. 2., upravené a rozšířené vydání. Praha: Vysoká škola chemicko-technologická v Praze, 2014. 410 s.
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MOFFAT, Anthony C., M. David OSSELTON, Brian WIDDOP a Jo WATTS (eds.). Clarke's Analysis of Drugs and Poisons: In Pharmaceuticals, Body Fluids and Postmortem Material. 4th edition. London: Pharmaceutical Press, 2011. 2 svazky..
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NELSON, Lewis S., Mary Ann HOWLAND, Neal A. LEWIN et al. Goldfrank's Toxicologic Emergencies. 11th edition. New York: McGraw-Hill Education, 2019..
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PELCLOVÁ, Daniela a kol. Nejčastější otravy a jejich terapie. 2., doplněné a rozšířené vydání. Praha: Galén, 2009. 163 s.
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ŠEVELA, Kamil, Pavel ŠEVČÍK a kol. Akutní intoxikace a léková poškození v intenzivní medicíně. 2., doplněné a aktualizované vydání. Praha: Grada, 2011. 328 s..
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Zákon č. 167/1998 Sb. v aktuálním znění (zákon o návykových látkách)..
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