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Lecturer(s)
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Hradil Pavel, prof. Ing. CSc.
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Course content
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1. Content of lecture, definition of basic terms, historical view 2. Separation of pharmaceutical production a. API b. Production of dosage forms 3. Documentation in chemical and pharmaceutical production a. technological reglement b. working instructions c. batch report 4. Legislative connected with pharmaceutical production ? inspection, FDA, SUKL, audits 5. Type of dosage forms, production and specific requirements 6. Academic and industrial view on chemical synthesis 7. Basic synthetic industrial methods ? heavy chemical industry and pharmaceutical industry 8. Waste and manipulation with them, possibilities of disposal. Future trends in production of drugs . 9. Globalization and changes in research, drug production and legislation. 10. Research project, selection, milestones, evaluation, patents and their function 11. Case studies, proposals of drug synthesis and their complex evaluation 12. Seminar work ? individual evaluation of various possibilities drug synthesis
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Learning activities and teaching methods
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Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook), Methods of Written Work
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Learning outcomes
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Student will understand to relationships between organic chemistry, industry and pharmacy and it is able to propose economic synthesis of drugs.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral exam, Written exam
Attendance at lectures, seminar work, passing of the written or oral exam.
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Recommended literature
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Hampl, Rádl, Paleček. Farmakochemie.
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Kleeman, Engel. Pharmaceutical Substances.
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