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Lecturer(s)
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Urban Milan, prof. RNDr. Ph.D.
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Course content
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Fundamentals of bioorganic chemistry - origin and contents; Macromolecules in living systems, structure, function and synthesis of biopolymers, self-assembly and self-organization; Amino acids and peptides -asymmetric synthesis of amino acids, synthesis of oligopeptides and their significance in medicine; Enzymes-immobilization of enzymes, host-guest complexation, use of enzymes in organic synthesis. Chemistry of phosphates and polynucleotides, mechanism and significance of intercalation and specific interactions of low-weight molecules with DNA; Antimetabolites-synthesis, application and significance; Metal ions-significance in proteins and biological molecules, mechanism of action; Chemical fundamentals of molecular recognition, fundamentals of supramolecular chemistry; Biomimetics in organic synthesis.
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Learning activities and teaching methods
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Lecture
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Learning outcomes
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Specialized course focusing on the fundamentals of bioorganic chemistry.
Define main concepts, describe main approaches in the bioorganic chemistry
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written exam
Write a midterm test during the semester at least 50% and a final test at least 50%, and then pass an oral exam.
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Recommended literature
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Dugas, H. (1996). Bioorganic Chemistry - A chemical approach to enzyme action. Springer.
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Patrick G. L. (2005). An Introduction to Medicinal Chemistry. Oxford.
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Vodrážka, Z., Krech, J. (1991). Bioorganická chemie. SNTL Praha.
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Waisser, K. Bioorganická chemie..
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