1. Introduction into the problematics. Biomimetic chemistry. Basic overview of interactions in living organism. Weak interactions in organic and biological world. Self-assembling, self-organization. Proximity effect in organic synthesis. 2. Bioorganic chemistry in living organisms. Chemistry of the Living Cells; Analogy Between Biochemical and Organic Reaction 3. Bioorganic chemistry of amino acids. Amino acids synthesis, asymmetric Synthesis. Comparison between synthesis and biosynthesis of proteins. Peptidomimetics, cyclic peptides, unnatural amino acids. Labelling of proteins, conjugates. 4. Bioorganic chemistry of enzymes. Introduction to Enzyme catalysis and kinetics. The catalytic triad. Enzyme inhibition and drug design. Enzyme in organic chemistry. Antibody catalyzed organic reaction. Enzyme models biomimetic polyene cyclization. Squalene biosynthesis. 5. Nucleic acids. History, sugars and bases. Conformation of sugar-phosphate backbone. Hydrogen bonding by bases; the double helix; A, B, and Z double helices. Stability of Double Helix. DNA intercalators. Chemical synthesis of DNA. Covalent interactions of nucleic acids with small molecules, reactions with nucleophiles, electrophiles. Reversible small molecule-nucleic acid interactions. Non-natural DNA structures. Artificial control of transcription. Molecular recognition of nucleic acids by proteins, nucleic acids, & small molecules. 6. Catalytic RNA, siRNA, micro RNA. Expanding the genetic alphabets background, synthesis and application of unnatural nucleosides. Fluorescently labeled nucleosides and oligonucleotide probes. Single nucleotide polymorphism (SNPs) and introducing Hap Map Project. Homogeneous DNA detection. Microarray based DNA detection. Basics of Peptide Nucleic Acids, concepts of Antigene/Antisense Therapy. Cleavage of nucleic acids. 7. Carbohydrates. Molecular intervention into carbohydrates metabolism. Synthesis of conjugates, xenobiotics. Oligosaccharides, polysaccharides, cyclodextrins. 8. Lipids. Cell membrane, biosynthesis. Cell transport. 9. Lipids. Liposomes and immunoliposomes. 10. Supramolecular chemistry. Cyclodextrins, fullerenes, calixarenes, rotaxanes, supramolecular chemistry of dendrimers. Photochemical sensors, molecular beacons, fluorescent labels. Modified nanoparticles.
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