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Lecturer(s)
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Stýskala Jakub, doc. RNDr. Ph.D.
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Course content
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1. Role of protective groups in organic synthesis, requirements to protection and deprotection reactions, strategy of use protective groups 2. Historical development of protective groups, development of new protective groups to nowadays 3. Protection for hydroxyl groups, including 1,2 and 1,3-diols 4. Protection for Phenols and Catechols 5. Protection for Carbonyl group 6. Protection for Carboxyl group 7. Protection for Thiol group 8. Protection for Amino group 9. Protection for Alkyne -CH 10. Protection for Phosphate group 11. Practicing to specific examples
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
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Learning outcomes
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The aim of this subject is focused to synthesis of more complex organic compounds with using protective groups. Attention is devoted to synthesis when chemical reaction is to be carried out selectively at one reactive site in a multifunctional compound. Students will learn how and which type of reagents to use for synthesis.
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Prerequisites
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Knowledge of organic chemistry
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Assessment methods and criteria
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Oral exam
Passing the oral exam.
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Recommended literature
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A.J. Pearson, W.R. Roush. (2000). Handbook of Reagents for Organic Synthesis - Activating Agents and Protecting Groups. John Wiley and Sons, inc.
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Theodora W. Greene, Peter G.M. Wuts. (1999). Protective Groups in Organic Syntheses. John Wiley and Sons, inc.
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