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Lecturer(s)
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Ulrichová Jitka, prof. RNDr. CSc.
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Course content
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Xenobiochemistry Metabolic activation Reactive oxygen and nitrogen forms (ROS and RNS ) Enzymatic and nonenzymatic antioxidants Oxidation stress, antioxidation capacity Pathobiochemistry of chronic diseases produced by radicals Skin damage by UV radiation, photodynamic therapy Side effects of drugs produced by radicals Determination methods of ROS and RNS. Laboratory methods monitoring oxidation damage Drugs in therapy of radical disorders Nutraceutics and supplements of food with antioxidation effect
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Learning activities and teaching methods
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Lecture
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Learning outcomes
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Specialized course focusing on the mechanism of action of enzymes, antioxidants and free radicals.
Explain main aspects, interpret problems, describe new trends
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Prerequisites
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pass lectures of biochemistry
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Assessment methods and criteria
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Oral exam
basic knowledge of biochemistry and organic chemistry
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Recommended literature
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Broekgaarden, M. (2023). Photodynamic Therapy. Springer, Berlin.
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Kalousová, M. Patobiochemie ve schématech. Grada.
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Kodíček, M. (2022). Biochemie. VŠCHT Praha.
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Koolman, J., Röhm, K. H. (2012). Barevný atlas biochemie. Praha: Grada.
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Kvasničková E. (1998). Xenobiochemie. FaF UK Praha.
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Rajnochová Svobodová, A. (2012). Poškození kůže působením slunečního záření, možnosti ochrany a prevence. UPOL.
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Štípek S. (2002). Antioxidanty a volné radikály ve zdraví a nemoci. Grada Publishing.
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