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Lecturer(s)
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Hradil Pavel, prof. Ing. CSc.
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Course content
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Students will be get acquainted with the content of the subject, basic terms and methods of evaluation of biological activity. Biologically active compounds occurring in nature in bacteria, moulds, mycetes, plants, and animals. Their structure, biological properties, history of their usage, and methods of their isolation or synthesis will be preferably studied. Important compounds with some applicability, for example pesticides, drugs or food contaminants will be selected in preference. Independent part will be focused on natural dyestuff. Changes of biological activity with structure of compounds and its different applicability will be shown on examples like dicumarol - warfarin, bromadiolone - ethylbiscumacetate; epibatidin - imidaclopride - ABT-594, and so on). These interconnections will be pointed out at the lessons dealing with pesticides and drugs. Pesticides and chemical weapons- main groups, their representatives, synthesis will be studied in the second part of the semester. Modern and used compounds, their metabolism and mode of the action will be emphasized.
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Learning activities and teaching methods
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Lecture
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Learning outcomes
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Specialized course focusing on the biologically active natural products and synthetic derivatives.
Student will understand to relation between natural compounds and pesticides, relations between biological activity and structure of molecules. Student receives an orientation in basic groups of biologically active compounds, pesticides and military compounds. He will know basic agents and their chemical synthesis.
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written exam
Attend lectures and write a test minimally on 70 %.
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Recommended literature
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Harborne J.B., Baxter H.: Dictionary of Plant Toxins, 1997 Cremlyn: Pesticidy, 1986 Melichar a kol.: Chemická léčiva, Avicennum 1986 Kornalík: Živočišné toxiny, 1968 Červinka a kol: Organická chemie, Praha 1985.
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