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Lecturer(s)
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Hradil Pavel, prof. Ing. CSc.
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Course content
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The lectures follow up "CBL 1". The main group of natural and synthetic compounds affecting CNS, compounds affecting vegetative nervous system, analgesics, gastrointestinal, cardiovascular, antiinfective drugs etc. Relations between structure in pharmacological groups and also relations between structure and biological activity in an individual group (for example in group of barbiturates, quinolinones, sulfonamides and so on). Adverse effect of drugs and possibilities of their modification by structural changes will be also discussed (for example terfenadine, thalidomide). In this subject also synthesis or isolation of drugs from natural sources, economical and historical aspects of individual compounds or groups of compounds will be mentioned. Also new synthetic methods of new molecules (like combinatorial chemistry), basic legislative in the research and production of drugs will be lectured.
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Learning activities and teaching methods
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Lecture
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Learning outcomes
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To learn students to ground of a pharmaceutical chemistry.
Basic knowledge of drug groups, their properties and chemical synthesis.
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Prerequisites
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unspecified
OCH/CBL1
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Assessment methods and criteria
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Oral exam, Written exam
Attend lectures; to write a test minimally on 70 % and pass an oral exam.
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Recommended literature
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Copeland R. A. (2005). Evaluation of Enzyme Inhibitors in Drug Discovery. John Wiley & Sons, Inc. Hoboken.
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Hampl F., Paleček J. (2015). Farmakochemie. VŠCHT Praha.
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Katzung B. G. (1994). Základní & klinická farmakologie. Nakladatelství a vydavatelství H &H.
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Kleemann A., Engel J. (2001). Pharmaceutical Substances. Thieme, Stutgart-New York.
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Lüllmann, H., Mohr, K., Wehling, M. (2004). Farmakologie a toxikologie. Praha, Grada Publishing.
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Melichar a kol. (1986). Chemická léčiva. Avicenum.
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Sweetman S. C. (2002). Martindale - The complete drug reference, 33th edition. Pharmaceutical Press.
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