| Course title | Chemical Biology 2 |
|---|---|
| Course code | OCH/CB2 |
| Organizational form of instruction | Lecture |
| Level of course | Master |
| Year of study | not specified |
| Semester | Winter |
| Number of ECTS credits | 4 |
| Language of instruction | Czech |
| Status of course | Compulsory |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Lecturer(s) |
|---|
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| Course content |
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1. Rational and combinatorial approach in drug development, chemical synthesis libraries. 2. Rational design of inhibitors of protein - protein interactions 3. Rational drug design to overcome drug resistance 4. Biomimetics 5. Chemical synthesis of peptides and peptide libraries and their testing. 6. Molecular modeling, prediction of the interaction of small molecules and proteins. 7. Software tool for analysis of cellular pathways, data types and formats of expression profiling. 8. Data visualisation chemical biology, SAR analysis and interpretation 9. Chemical genetics / SCIBS, genomics, methods, and applications, nucleic acids and their interaction with small molecules. 10. Protein expression , rational design of proteins, phage display. 11. Proteomics, proteomic methods in search of targets of small molecules, DARTS, SILAC, immunoaffinity purification. 12. PCR, RT-PCR validation of targets, mutagenesis, zinc-finger nucleases, microarrays and their use in chemical biology
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| Learning activities and teaching methods |
| Lecture |
| Learning outcomes |
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Student will be introduced to the applications of chemical biology in drug development
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| Prerequisites |
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unspecified
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| Assessment methods and criteria |
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Oral exam
Knowledge of the subject matter (syllabus) and recommended literature. |
| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester | |
|---|---|---|---|---|
| Faculty: Faculty of Science | Study plan (Version): Bioorganic Chemistry and Chemical Biology (2020) | Category: Chemistry courses | 2 | Recommended year of study:2, Recommended semester: Winter |