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Lecturer(s)
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Kryštof Vladimír, prof. RNDr. Ph.D.
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Daněk Petr, Mgr. PhD.
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Course content
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Basic characterization and classification of immune cells, surface markers and flow cytometry, ontogeny and hematopoietic differentiation. Distribution of leukocytes in tissues, cellular and molecular aspects of inflammatory processes. Molecular mechanisms of immune cell action in organs, influence of circadian rhythms. Dual role of immune cells - wound healing and regeneration. Role of immune cells in pathological processes and molecular mechanisms of their action. Influence of metabolism and lifestyle on immune cell function, association of local and systemic inflammation with diabetes, metabolic syndrome, low-grade systemic inflammation, molecular basis of these processes. Influence of the microbiome on immune cell function. Hallmarks of cancer, neoantigens, molecular and cellular mechanisms of anti-tumor immune response, tumor microenvironment. Molecular mechanisms of tumor immunosuppression. Immunotherapy - immune checkpoint inhibitors, therapeutic antibodies, therapeutic cytokines, cell-based therapies, biomarkers for immunotherapy deployment, adverse effects of immunotherapies, anti-drug antibodies.
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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Expansion of knowledge in immunology, molecular basis of related physiological and pathophysiological processes, their use in treatment.
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Prerequisites
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Knowledge of general, cellular and molecular biology and animal physiology is an advantage.
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Assessment methods and criteria
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unspecified
Successful completion of the oral exam - discussion on a selected topic
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Recommended literature
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Hořejší V., Bartůňková J. (2017). Základy imunologie. Triton Praha.
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Slabý, O., et al. (2015). Molekulární medicína. Praha Galén.
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