| Course title | Development and Production of Vaccines |
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| Course code | KBC/VVO |
| Organizational form of instruction | Lecture |
| Level of course | Master |
| Year of study | not specified |
| Semester | Winter |
| Number of ECTS credits | 2 |
| Language of instruction | Czech |
| Status of course | Compulsory-optional, Optional |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Lecturer(s) |
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| Course content |
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1. Introduction, history of vaccination, basic terms from epidemiology and infectology. 2. Basic immune mechanisms used in anti-infection immunity. 3. Types and composition of vaccines. Polyvalent and combined vaccines. Pharmaceutical forms of vaccines. 4. Vaccine production technology I- attenuated and inactivated vaccines. 5. Technology of vaccine production (li - subunit vaccines (split, polysaccharide) and toxoids). 6. Technology of production of vaccines Ill-recombinant vaccines, production and purification of recombinant proteins). 7. IV vaccine production technology - gene vaccines - RNA and DNA. 8. Technology of vaccine production V - recombinant viruses replication defective and attenuated, mucosal vaccines. 9. Immunogenicity and safety testing I - clinical and preclinical testing, effectiveness tests on an animal model, determination of specific antibodies in-vitro, tests for the presence of contaminants). 10. Immunogenicity and safety testing - viral neutralization tests, cellular immunity tests - ELISPOT, lymphocyte activation. 11. Legislative standards on vaccination (Laws No. 258/2000 Coll., No. 378/2007 Coll. and No. 48/1997 Coll., Decree No. 537/2006 Coll.), registration and registration authorities, adverse effects vaccines and their monitoring. 12. News in the field, discussion, final test.
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| Learning activities and teaching methods |
Lecture, Dialogic Lecture (Discussion, Dialog, Brainstorming)
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| Learning outcomes |
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An introduction to both classic and state-of-the-art approaches of vaccine production technologies.
Getting to know the basic terms and principles associated with the production and use of vaccines. Acquaintance with classic and modern vaccine production technologies. |
| Prerequisites |
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Basic knowledge of biochemistry and immunology.
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| Assessment methods and criteria |
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Mark, Written exam
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| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester | |
|---|---|---|---|---|
| Faculty: Faculty of Science | Study plan (Version): Biochemistry (2022) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Winter |
| Faculty: Faculty of Science | Study plan (Version): Analytical Biochemist (2024) | Category: Chemistry courses | - | Recommended year of study:-, Recommended semester: Winter |
| Faculty: Faculty of Science | Study plan (Version): Biotechnology and Genetic Engineering (2019) | Category: Chemistry courses | 1 | Recommended year of study:1, Recommended semester: Winter |