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Lecturer(s)
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Šebela Marek, prof. Mgr. Dr.
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Luhová Lenka, doc. RNDr. Ph.D.
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Course content
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Structure and function of proteins. Enzymes. Saccharides. Lipids and cell membranes. Catalytic strategies. Regulatory strategies. Regulation of metabolic pathways: glycolysis, gluconeogenesis, citrate cycle, oxidative phosphorylation, light reactions of photosynthesis, Calvin cycle, pentose phosphate pathway, metabolism of glycogen, metabolism of fatty acids, protein turnover and catabolism of amino acids, biosynthesis of amino acids, biosynthesis and degradation of nucleotides. Replication of DNA, recombination and correction. RNA synthesis and its function. Protein synthesis. Functions of tRNA, mRNA and ribosomes. Prokaryotic and eukaryotic synthesis of proteins. Inhibitors of protein biosynthesis. Regulation of gene expression. Integration and regulation of mammalian energetic metabolism.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming)
- Preparation for the Exam
- 50 hours per semester
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Learning outcomes
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Get possession of complex and substantial knowledges of metabolic patheways, reciprocal interconnection and regulation.
Integrate knowledge, summarize the causes and effects in primary metabolism
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Prerequisites
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Successful graduated studium of Bachelor of Science and Magister of Science in Biochemistry.
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Assessment methods and criteria
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Oral exam
Oral examination - successfuly answered three questions of general knowledge.
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Recommended literature
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Koolman J., Rohm KH.:. (2012). Barevný atlas biochemie, 4.vydání. Grada 2012.
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Nelson, D.L., Cox M.M. Lehninger Principles of Biochemistry, Nakladatel: Palgrave Macmillan, 2017, ISBN: 9781319108243.
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Voet D., Voet, Judith G., Pratt, Charlotte W. (2006). Fundamentals of Biochemistry. New York.
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