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Lecturer(s)
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Course content
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Molecular structure of biological membrane and transport mechanism across cell membrane. Drug transporters. Pharmacokinetics - single and multiple dose therapy, single and multiply compartment models, bioavailability. Factors influencing drug absorption. Drug distribution - blood brain, barrier, placental barrier, Volume of Distribution. Drug excretion - renal and non renal. Biotransformation of drugs - microsomal, non-microsomal metabolism, factors influencing, enzyme induction and inhibition. Molecular targets of drugs. Theories of drug receptors and drug receptor interactions. Dose-response curve. Cellular and molecular basis of drug action. Second messengers. Signal transduction pathways. Neurotransmitters in CNS. Pharmacogenetics. Targeted therapy.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
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Learning outcomes
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Molecular structure of biological membrane and transport mechanism across cell membrane. Drug transporters. Pharmacokinetics - single and multiple dose therapy, single and multiply compartment models, bioavailability. Factors influencing drug absorption. Drug distribution - blood brain, barrier, placental barrier, Volume of Distribution. Drug excretion - renal and non renal. Biotransformation of drugs - microsomal, non-microsomal metabolism, factors influencing, enzyme induction and inhibition. Molecular targets of drugs. Theories of drug receptors and drug receptor interactions. Dose-response curve. Cellular and molecular basis of drug action. Second messengers. Signal transduction pathways. Neurotransmitters in CNS. Pharmacogenetics. Targeted therapy.
Student will be able to - conduct scientific discussion in broader context of the whole discipline - summarize molecular pharmacology knowledge - explain molecular pharmacology techniques
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral exam
Exam in extent of the lecture
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Recommended literature
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Josephy, D., Mannervik, B. Molecular Toxicology, Academic Press, New York, 2006..
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Rang, H.P., Dale, M.M., Ritter, J.M. (2003). Pharmacology. 5th ed., Churchill Livingstone, Edinburgh.
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