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Lecturer(s)
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Dvořák Zdeněk, prof. RNDr. DrSc.
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Course content
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Structure and function of proteins. Structure and function of nucleic acids: DNA, mRNA, tRNA, rRNA, ribozymes, small RNA molecules. Genetic code. Genes, transcription, translation, replication. Mechanisms of mutations. DNA repair mechanisms. DNA recombination. Hybridization of nucleic acids, blotting techniques. Polymerase chain reaction. Basic cellular targets. Enzymes - enzyme kinetics, regulation of enzyme activity. Cytoskeleton and its function. Cell signalling - signal molecules, signalling pathways. Receptor theory. Nuclear ans steroid receptors. G-coupled protein receptors - physiological functions, molecular pharmacology functions. Neurotransmitters - nervous system in man, metabolism, mechanism of action, therapeutic potential. Proteasom-ubiqitine system. Metabolism of xenobiotics. Cellular toxicology - mechanisms of cellular damage, repair and defense mechanisms.
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Learning activities and teaching methods
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Dialogic Lecture (Discussion, Dialog, Brainstorming), Work with Text (with Book, Textbook)
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Learning outcomes
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Macromolecules - their structure and function. Replication and gene expresion. Structure and organization of genetic information and their changes. Modern mMolecular techniques used in their study. Cytoskeleton and its function. Enzymes - enzyme kinetics, regulation of enzyme activity. Cell signalling - signal molecules, signalling pathways. Receptor theory. Neurotransmitters. Proteasom-ubiqitine systém. Metabolism of xenobiotics and cellular toxicology.
Student will be able to: - summarize molecular and cellular biology knowledge - explain molecular and cellular biology techniques - conduct scientific discussion in broader context of the whole discipline
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Prerequisites
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unspecified
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Assessment methods and criteria
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Oral exam
PhD exam
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Recommended literature
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Alberts a kol. (2002). Molecular Biology of the Cell. New York.
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Rang, H.P., Dale, M.M., Ritter, J.M. (2003). Pharmacology. 5th ed., Churchill Livingstone, Edinburgh.
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