| Course title | Population Genetics |
|---|---|
| Course code | KBB/PG |
| Organizational form of instruction | Lecture + Seminar |
| Level of course | Bachelor |
| Year of study | not specified |
| Semester | Winter |
| Number of ECTS credits | 4 |
| Language of instruction | Czech |
| Status of course | Compulsory, Compulsory-optional |
| Form of instruction | Face-to-face |
| Work placements | This is not an internship |
| Recommended optional programme components | None |
| Lecturer(s) |
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| Course content |
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Lectures: History of population genetics, genetic variation in populations, polymorphic loci, genotype and allele frequencies, estimates of genotype and allele frequencies, heterozygosity, polymorphism, molecular variation. Mathematical models, random mating, Hardy-Weinberg principle and its applications, deviations from Hardy-Weinberg equilibrium, sex and Hardy-Weinberg principle, recessive alleles, Snyder's ratios. Hardy-Weinberg principle for multiple alleles, Bruce's ratios, genes on X chromosome. Hardy-Weinberg principle for 2 genes, linkage equilibrium and disequilibrium. Assortative mating, inbreeding, inbreeding coefficient, inbreeding and its influences, inbreeding in human populations, inbreeding coefficient calculations from genealogical diagrams. Genetic drift and its effect in populations, population structure, probability of fixation for a new mutation, effective population size, founder effect, population bottlenecks. Mutations, kinds of mutations, theory of neutrality, Weismann barrier. Migration (gene flow), population subdivision and F coefficient, island model, Wahlund effect, estimates of gene flow. Natural selection, fitness, haploid and diploid model of natural selection at single locus, adaptive topography, stabilizing, directional and disruptive selection. Genetics of sex, sex reproduction, Muller's ratchet, determination of sex, male/female ratio, unusual sex ratio in populations. Eugenics, history of eugenics, dysgenic factors in human, dysgenic factors in history of the Czech Republic, r and K strategy, present genetic deterioration in human, eugenic programs, eugenic and ethical problems, eugenics in future. Molecular methods in population genetics. Seminars: Calculations and estimations of alleles and genotypes frequencies, Hardy-Weinberg equilibrium, recessive alleles, Snyder's ratios, Hardy-Weinberg principle for 3 alleles, Bruce's ratios, Hardy-Weinberg principle for 2 genes, genes on X chromosome, Bruce's ratios, nonrandom mating, inbreeding coefficient, inbreeding coefficient calculations from genealogical diagrams, effective population size, genetic drift, mutations, migration, Wahlund effect, natural selection.
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| Learning activities and teaching methods |
| Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Demonstration |
| Learning outcomes |
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Populations and their variability. Alleles equilibrium in different types of populations a mechamisms which can destroy equilibrium in populations (mutation, migration, selction, drift and inbreeding).
Student is able to (after attending the course): - Describe the history of population genetics and list the most important population geneticists. - Explain the terms used in population genetics. - Explain the population genetics models. - Explain the gene flow. - Explain the genetics of sex and its consequences for population genetics. - Characterise the eugenics and its history. - Calculate and estimate the alleles and genotypes frequencies, Hardy-Weinberg equilibrium, recessive alleles, Snyder's ratios, Hardy-Weinberg principle for 3 alleles, Bruce's ratios, Hardy-Weinberg principle for 2 genes, genes on X chromosome, Bruce's ratios, nonrandom mating, inbreeding coefficient, inbreeding coefficient calculations from genealogical diagrams, effective population size, genetic drift, mutations, migration, Wahlund effect, natural selection. |
| Prerequisites |
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unspecified
KBB/GENOM ----- or ----- KBB/OGPSB |
| Assessment methods and criteria |
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Oral exam, Student performance, Seminar Work
80% attendance credits: work out 2/3 questions in test exam in extent of the lectures |
| Recommended literature |
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| Study plans that include the course |
| Faculty | Study plan (Version) | Category of Branch/Specialization | Recommended semester | |
|---|---|---|---|---|
| Faculty: Faculty of Science | Study plan (Version): Biology and Ecology (2020) | Category: Biology courses | 3 | Recommended year of study:3, Recommended semester: Winter |
| Faculty: Faculty of Science | Study plan (Version): Molecular and Cell Biology (2021) | Category: Biology courses | 3 | Recommended year of study:3, Recommended semester: Winter |