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Lecturer(s)
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Sokolová Barbora, Mgr. Ph.D.
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Course content
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Introduction with the history of toxicology, subfielts of toxicolgy with focussing to clinical and forensic toxicology. The effect of xenobiotics and their mechanism at the molecular level (pharmacodynamics) is discussed, as well as, the fate of xenobiotics in human organism (pharmacokinetics, respectively toxicokinetics). Individual groups of psychoactive compounds, significant noxae in acute intoxication, overdose drugs, abuse are discussed. A description of the methods of analytical toxicology is given regarding their limitations related to the nature of analytes and biological material (the systematic toxicology analyse of unknown noxa). The last of the course is engaged in legal aspects of psychoactive compounds.
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Learning activities and teaching methods
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unspecified
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Learning outcomes
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The aim of the course is to introduce students with the basics of clinical and forensic toxicology ? the most important groups of psychoactive compounds, the effects of psychotropic coumpands on human organism, effects of drug abuse and drug dependence and problems of analytical toxicology.
Student is able after attending the course: - basics of pharmacodynamics and pharmacokinetics, respetively toxicokinetics - knowledge of the most psychotropic compounds, significant noxae in acute intoxication, overdose drugs, abuse - analytical toxicology - the systematic toxicology analyse of unknown noxa - legal aspects
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Prerequisites
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unspecified
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Assessment methods and criteria
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unspecified
70% test
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Recommended literature
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Balíková, M. (2017). Forenzní a klinická toxikologie. Galén Praha.
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Dostálek, M. (2006). Farmakokinetika. Grada Publishing, Praha.
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Katzung B. G. (2006). Základní a klinická farmakologie. H&H.
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Lüllmann, H., Mohr, K., Wehling, M. (2002). Farmakologie a toxikologie. . Grada Publishing., Praha.
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