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Lecturer(s)
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Petr Jan, doc. RNDr. Ph.D.
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Course content
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1. Microtechniques in analytical chemistry - introduction, principles and specific aspects of miniaturization 2. Microscopic techniques and mechanical operations at the nanoscale - atomic force microscopy 3. Microfluidics - basic principles and theoretical description 4. Microfluidics - materials and fabrication technologies for microfluidic devices 5. Microfluidics - surface properties and modification, flow regulation 6. Microfluidics - flow control and mixing in microfluidic systems 7. Microfluidics - chemical reactions and separation processes on chips 8. Microfluidics - detection principles and their integration 9. Microfluidics - applications, PCR and sequencing technologies 10. Low-cost microfluidics - materials, fabrication approaches and applications
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Learning activities and teaching methods
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Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming)
- Attendace
- 26 hours per semester
- Preparation for the Exam
- 34 hours per semester
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Learning outcomes
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The aim of the course is to introduce students to the principles of modern analytical techniques performed at the microscale and to miniaturized analytical methods. Emphasis is placed on the specific aspects of miniaturization, the basic principles of microfluidics, the design and properties of microfluidic systems, and their applications in analytical chemistry.
Upon completion of the course, students will understand the basic principles of miniaturized analytical methods and microfluidic systems. They will be able to describe the principles of their design and operation, characterize basic approaches to flow control, separation, and detection, and assess the potential use of miniaturized systems for selected analytical problems.
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Prerequisites
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Basic knowledge of analytical chemistry and instrumental methods of analytical chemistry is recommended for successful completion of the course.
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Assessment methods and criteria
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Written exam
The examination is conducted in written form as a test consisting of open-ended questions. To pass the examination, students must achieve at least 60% of the total score.
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Recommended literature
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A. Folch. How the World Flows: Microfluidics from Raindrops to Covid Tests. Oxford University Press 2025.
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A. Folch. Introduction to BioMEMS. CRC Press 2012..
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A. Manz, P. Neužil, J.S. O?Connor, S. Simone. Microfluidics and Lab-on-a-chip. RSC 2020..
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C. H. Li. (2005). Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery.
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J. P. Landers. (2007). Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques.
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P. Tabeling. (2006). Introduction to Microfluidics.
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Z. El Rassi. Advances in Microscale Electro- and Liquid Phase-Based Separation Techniques. Elsevier 2026.
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