Course: Osteoimmunology

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Course title Osteoimmunology
Course code PFY/VCA43
Organizational form of instruction Seminar
Level of course Master
Year of study not specified
Semester Winter
Number of ECTS credits 2
Language of instruction Czech
Status of course Compulsory-optional, Optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Petřek Martin, prof. MUDr. CSc.
  • Navrátilová Zdenka, doc. Mgr. Ph.D.
  • Petřková Jana, doc. MUDr. Ph.D.
Course content
1. Introduction into osteoimmunology. Definition, scope of the discipline, its origin and development. Bone multicellular unit and its regulatory networks. 2. Methodical approaches in osteoimmunology. Examination of patient, laboratory investigations, paging. Spectrum of patients and thein clinical characteristics. 3. Application of osteoimmunological approaches for differential diagnostics of musculoskeletal disorders, for stratification and disease development prediction. 4. Contribution of osteoimmunology to search for biomarkers / target molecules of biological treatment. Trends and challenges of osteoimmunology.

Learning activities and teaching methods
Monologic Lecture(Interpretation, Training), Dialogic Lecture (Discussion, Dialog, Brainstorming), Demonstration
Learning outcomes
Student will get acquainted with basis of new, dynamically-developing discipline, in which immunology meets the clinical aspects of musculoskeletal disorders. After introductory review of theoretical aspects, clinical specialists will discuss applications into diagnostics and treatment of socioeconomically important disease such as osteoarthritis, osteoporosis, tumour osteolysis etc.), and complications of therapy such as osteolysis after total joint arthroplasties.
Graduates should be able to involve osteoimmunological approaches into the care about musculoskeletal diseases. Knowledge of methodology and analytical aspects is applicable in postgradual study and also in pregradual research practice.
Prerequisites
not specified.
BIO/VCA11
----- or -----
BIO/ZUA11 and BIO/VCB11
----- or -----
BIO/ZUB11 and LCH/VCA21
----- or -----
LCH/ZUB21 and KIM/VCB12
----- or -----
KIM/ZUA12 and CH0/VCA11
----- or -----
IN1/ZUA12

Assessment methods and criteria
Student performance, Dialog

Requirements: Participation in the seminars. In accordance with Directive of the dean of the faculty of medicine and dentistry LF-B-18/14, article 7. item 1, Department sets the following limit for absences: 1 teaching hour (45 min., 12,5%) without apologies. Absence above the limit due to substantial causes must be justified by the main teacher with a proper substitution. With regard to the specialized character of the subject and its low hourly subsidy, we recommend completing the entire course.
Recommended literature
  • Caetano-Lopes, J. (2009). Osteoimmunology: hidden immune regulation of bone. Autoimmun Rev 2009/8, str. 250-55.
  • Gallo, J., Konttinen, Y. T., Goodman, S. B., Thyssen, J. P., Gibon, E., Pajarinen, J., Takakubo, Y., Schalock, P., Mackiewic, Z., Jämsen, E., Petrek, M. (2012). Aseptic loosening of total hip arthroplasty as a result of local failure of tissue homeostasis. In Fokter, S. K. Recent Advances in Arthroplasty.. Intech.
  • Lorenzo J, Horowitz M, Choi Y, Takayanagi H, Schett G. Osteoimmunology: Interactions of the Immune and Skeletal Systems.
  • Schett, G. Osteoimmunology in rheumatic disease. Arthritis Research & Therapy, 2009, vol. 11, p. 210.


Study plans that include the course
Faculty Study plan (Version) Category of Branch/Specialization Recommended year of study Recommended semester
Faculty: Faculty of Medicine and Dentistry Study plan (Version): General Medicine (2019) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter
Faculty: Faculty of Medicine and Dentistry Study plan (Version): Dentistry (2019) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter
Faculty: Faculty of Medicine and Dentistry Study plan (Version): - (2021) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter
Faculty: Faculty of Medicine and Dentistry Study plan (Version): General Medicine (2021) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter
Faculty: Faculty of Medicine and Dentistry Study plan (Version): General Medicine (2018) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter
Faculty: Faculty of Medicine and Dentistry Study plan (Version): Dentistry (2019) Category: Medical sciences 3 Recommended year of study:3, Recommended semester: Winter