In the past 10 years the amount of data, stored in the greatest structural database, has risen in one order and the amount of sequential data has risen even in two orders. Structural bioinformatics is a field of study of these structural data towards biological scope. 1. Indroduction, structure to function relationships 2. Protein structure basics - levels of structure, physico-chemical properties of aminoacids and nucleic acids, rotameric libraries, Molecular interactions 3. Terciární struktura proteinů, proteinová architektura a topologie, protein evolution 4. Nucleic acids structure basics - levels of structure 5. Experimental structure elucidation, NMR vs X-ray vz Cryo-EM, resolution and structure validation 6. Structural bioinformatics databases 7. Structure alignment, RMSD, superposition algorithms, DALI, MAMMOTH 8. Structure prediction - homology modelling, threading, ab initio, covariance 9. Function prediction - surface, active site, channels, disorder, membrane, ligand positions 10. Protein-protein and protein-nucleic acid interactions
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